Know enough to decide for yourself.

August 26, 20265 min read

FIGO and IMS: Treat Early Menopause as a Chronic Condition

On 18 August 2026, the International Federation of Gynecology and Obstetrics (FIGO) and the International Menopause Society (IMS) published a joint position paper in...

August 24, 20264 min read

Menopausal Hormone Therapy and Grip Strength After Age 60

On July 28, 2026, the Journal of Applied Physiology published an analysis that put a number on something women in midlife often ask about and rarely see measured....

August 23, 20265 min read

GLP-1s and Sleep Apnea: What 5 Randomized Trials Found

On August 18, 2026, the journal Otolaryngology-Head and Neck Surgery, published on behalf of the American Academy of Otolaryngology-Head and Neck Surgery Foundation,...

August 20, 20265 min read

Tirzepatide's Triple Endpoint: Weight, Blood Pressure, Lipids

On August 13, 2026, PLOS ONE published a post hoc analysis of all four SURMOUNT trials that asks a question the original trials were not designed to answer: how...

August 19, 20265 min read

GLP-1s and Testosterone: What Eight Human Studies Found

On 23 July 2026, the journal Cells published a systematic review that asked a question the literature had only answered in scattered pieces: when a man's...

August 18, 20264 min read

GLP-1 Drugs and Fatty Liver: What 27 Trials Found

Yes, and by a wide margin: a pooled analysis of 27 randomized controlled trials in 2,687 adults with metabolic dysfunction-associated steatohepatitis (MASH),...

August 16, 20265 min read

How GLP-1s Produce Weight Loss, According to Four Trials

GLP-1 medications produce weight loss mainly by making people eat less, not by burning more calories at rest. Four randomized trials measured that mechanism...

August 14, 20265 min read

Louisiana's Act 374 and Compounded Peptides: What Changed

On August 1, 2026, a two-paragraph addition to Louisiana law took effect. Act 374 created R.S. 37:23.5, and it does one narrow thing: it tells state professional and...

August 13, 20265 min read

GLP-1s Before Joint Replacement: The 90-Day Outcome Data

If you take a GLP-1 medication and a hip or knee replacement is on your horizon, you have probably wondered whether the drug helps you through the operation or...

August 12, 20265 min read

Adding Exercise to a GLP-1: What Nine Trials Found

On 13 July 2026, the journal Obesity Reviews published a network meta-analysis ranking GLP-1 receptor agonist therapy, structured exercise, and the two combined...

August 10, 20265 min read

Does Tirzepatide Lower Heart Risk? What 22 Trials Found

Yes, largely: a July 2026 meta-analysis of 22 randomized trials pooling 29,023 people found that tirzepatide lowered the odds of major cardiovascular events by 13%...

Tirzepatide Plus a Psoriasis Biologic: What the Trial Found

In July 2026, JAMA Dermatology published the results of TOGETHER-PsO, the first phase 3 randomized trial to treat plaque psoriasis and obesity at the same time and...

August 6, 20265 min read

51 Trials on Hormone Therapy, Mood, Anxiety, and Sleep

Hormone therapy improved depression, anxiety, mood, and sleep quality scores in the largest randomized evidence base yet assembled on menopausal psychological...

August 5, 20265 min read

FDA Panel Backs BPC-157, TB-500 and KPV for the 503A List

On July 23 and 24, 2026, the FDA's Pharmacy Compounding Advisory Committee voted on seven peptides and recommended six of them for the 503A Bulks List. BPC-157, KPV...

August 4, 20265 min read

Tesamorelin: What Four Pooled Trials in 909 Patients Found

A meta-analysis published July 31, 2026 in the Journal of the International Association of Providers of AIDS Care pooled all four randomized controlled trials of...

August 3, 20265 min read

Visceral Fat, Not BMI, Tracks With Low Testosterone

A cross-sectional analysis published July 13, 2026 in the Journal of the Endocrine Society answers a question a lot of men have put to their doctors: if my weight is...

August 2, 20264 min read

Longevity

NAD+: What the Human Evidence Actually Supports

NAD+ is one of the most confidently marketed molecules in longevity medicine, and one of the most honestly uncertain. Both of those things are true at once, and the...

Enclomiphene vs Testosterone: What Trials Compared

If your testosterone is low, there is more than one way to change that number, and the routes are not equivalent in what else they do.

Sermorelin and the GHRH Peptides, Explained

Sermorelin comes up constantly in conversations about recovery, sleep, and body composition, usually described as a gentler alternative to growth hormone. The...

How Tirzepatide Works: Two Hormones, Not One

Tirzepatide gets described as a GLP-1 medication, which is close enough to be useful and wrong enough to be worth correcting. It acts on two receptors, not one, and...

July 25, 20264 min read

Three Years of Tirzepatide: What the Trial Found

Most weight loss studies run for a few months. That is long enough to show that something works and far too short to answer the question people actually have, which...

What the FDA Just Reviewed About Seven Peptides

On July 23 and 24, 2026, the FDA's Pharmacy Compounding Advisory Committee met at the agency's White Oak campus to review seven peptides. The question in front of...